18 Sep 2025: A groundbreaking study has revealed that cocoa extract supplements, rich in flavanols, could play a pivotal role in slowing the aging process and reducing the risk of death from heart disease. This research, conducted by Brigham and Women’s Hospital in collaboration with Mass General Brigham, is part of the extensive COcoa Supplement and Multivitamin Outcomes Study (COSMOS). The findings offer promising insights into the potential health benefits of chocolate-derived supplements.
The COSMOS Trial: A Comprehensive Investigation
The COSMOS trial is one of the largest and most comprehensive studies examining the health effects of cocoa flavanols. Spanning several years, it involved over 21,000 participants aged 60 and above. The primary aim was to assess the impact of daily cocoa extract supplementation on cardiovascular health and aging-related inflammation, known as “inflammaging.”
Key Findings:
- Reduction in Inflammation: Participants who consumed daily cocoa extract supplements exhibited an annual 8.4% decrease in high-sensitivity C-reactive protein (hsCRP) levels. HsCRP is a protein associated with inflammation and heart disease risk.
- Decreased Cardiovascular Mortality: Earlier analyses from the COSMOS study indicated a 27% reduction in cardiovascular disease-related deaths among those taking cocoa supplements.
- Enhanced Immune Response: The study also observed an increase in interferon-γ, a cytokine involved in immune regulation, suggesting that cocoa flavanols may bolster the body’s defense mechanisms.
Mechanisms Behind the Benefits
Cocoa flavanols are potent antioxidants that can improve endothelial function, reduce blood pressure, and enhance blood vessel elasticity. These effects collectively contribute to better cardiovascular health and may mitigate age-related decline in vascular function. Moreover, by modulating inflammatory pathways, cocoa flavanols address the underlying processes of inflammaging, potentially slowing the onset of age-associated diseases.
Practical Implications
While the study’s results are promising, researchers emphasize that cocoa supplements should complement, not replace, traditional heart-healthy practices. Incorporating a balanced diet, regular physical activity, and routine medical check-ups remains essential. Additionally, it’s important to note that the cocoa supplements used in the study were specifically formulated to contain high levels of flavanols, unlike many commercially available chocolate products that may have added sugars and fats.
City Perspective: Liverpool’s Role in Health Research
Liverpool, renowned for its contributions to medical research, continues to be at the forefront of health innovations. Institutions like the University of Liverpool and Liverpool John Moores University collaborate with global partners to conduct pivotal studies. The recent findings on cocoa supplements further cement the city’s reputation as a hub for groundbreaking health research.
Summary
A recent study indicates that cocoa extract supplements can reduce inflammation and lower the risk of cardiovascular disease-related deaths, offering a potential strategy for healthy aging and heart disease prevention.