October 27, 2025 : A medical expert has issued a caution about certain commonly prescribed medications that can lead to a dangerous drop in sodium levels — a condition known as hyponatremia — causing symptoms like weakness, confusion, and fatigue.
According to health specialists, sodium is an essential electrolyte that helps regulate fluid balance, nerve function, and muscle activity. However, some medicines, especially those prescribed for high blood pressure, depression, and pain management, can inadvertently reduce sodium levels in the body.
Dr. Anita Mehra, an internal medicine specialist, explained that diuretics (water pills) — often given to patients with hypertension or heart conditions — are among the top culprits. “These medications help remove excess fluid from the body but can also flush out essential sodium,” she said. “If the loss is significant, it may cause muscle weakness, dizziness, headaches, or even confusion.”
Other drugs that can contribute to hyponatremia include antidepressants (SSRIs and SNRIs) and certain pain medications such as non-steroidal anti-inflammatory drugs (NSAIDs). The risk increases in older adults, people with kidney issues, or those who drink excessive amounts of water while on medication.
Dr. Mehra emphasized the importance of routine blood tests for anyone on long-term medication. “Patients should not stop taking their prescribed drugs abruptly,” she cautioned. “Instead, they should consult their doctor if they experience persistent fatigue, muscle cramps, or nausea.”
She added that maintaining a balanced diet with adequate salt intake and staying hydrated can help minimize risk. However, individuals with specific medical conditions — like heart failure or chronic kidney disease — should follow their doctor’s dietary advice carefully.
Healthcare professionals recommend being extra vigilant during hot weather or illness, as sweating and dehydration can worsen sodium imbalance.
“Awareness is key,” Dr. Mehra concluded. “Many people attribute weakness or tiredness to stress, when in reality, their sodium levels might be too low because of medication.”
Summary
Doctors caution that medications for high blood pressure, depression, and pain relief can cause low sodium levels, leading to weakness and confusion. Regular monitoring and medical guidance are advised for patients.